Clinical manifestations of dry syndrome The onset of this disease is more concealed and its clinical manifestations are diverse. 1. Local manifestations (1) Sjogren's disease causes the following common symptoms because of salivary gland lesions, which lead to the lack of salivary mucin: (1) Most patients complain of dry mouth. Serious patients suffer from sticky oral mucosa, teeth and tongue, so that they often need to drink water when speaking and must be delivered with water or flowing food when eating solid food.(2) rampant dental caries is one of the characteristics of this disease.About 50 patients suffered from multiple caries which were difficult to control. The manifestation was that the teeth gradually became black, then small pieces fell off, and finally only residual roots remained.(3) Adult mumps, 50 patients with intermittent alternating parotid swelling and pain, involving unilateral or bilateral.Most of them can subside spontaneously in about 10 days, but sometimes they have persistent enlargement.A few of them had submandibular gland enlargement and less sublingual gland enlargement.(4) The tongue is characterized by tongue pain, dry and cracked tongue surface, atrophy and smooth tongue papilla.(5) ulcer or secondary infection of oral mucosa. (2) Dry keratoconjunctivitis, due to the decrease of mucin secreted by the lacrimal gland, has symptoms of dry eyes, foreign body sensation, and less tears. Serious cases cry bitterly without tears.Some patients have recurrent suppurative infection of eyelid margin, conjunctivitis, keratitis, etc. (3) The exocrine glands of other superficial parts, such as nose, hard palate, trachea and its branches, digestive tract mucosa and vaginal mucosa, can be involved, so that they secrete less and have corresponding symptoms. 2. System Performance In addition to dry mouth and eyes, patients can also have systemic symptoms, such as fatigue, low fever and so on.About two-thirds of patients suffered from systemic damage. (1) Allergic purpura-like skin rash can occur on the skin, mostly in the lower extremities. It is a red papule with clear boundaries between the size of rice grains. It does not fade under pressure and appears in batches.Each batch lasts about 10 days, and can fade away by itself with brown pigmentation. (2) Joint pain is more common, and there is no destruction of joint structure. (3) About half of the patients with kidney damage, mainly involving distal renal tubules, can appear renal tubular acidosis.A small number of patients have obvious glomerular damage, clinical manifestations are massive proteinuria, hypoalbuminemia, and even renal insufficiency. (4) Most patients with lung have no respiratory symptoms.Dry cough occurred in mild patients and shortness of breath in severe patients.The main pathological changes of the lungs were interstitial lesions, and a small number of patients had pulmonary hypertension.The prognosis of patients with pulmonary fibrosis and severe pulmonary hypertension is poor. (5) Non-specific symptoms such as atrophic gastritis, decreased gastric acid and indigestion may occur in the digestive system, and liver damage may occur in patients. (6) A few nerves involve the nervous system.Peripheral nerve damage is common. (7) Leukocyte count and/or thrombocytopenia may occur in this disease of the blood system, and bleeding may occur in patients with severe thrombocytopenia.The incidence of lymphoma is much higher than that of normal population.